Diagnostic de l’intoxication digitalique et son traitement. Ferrero C. Author affiliations. Clinique universitaire de Médecine Interne, Hôpital Cantonal, Genève . Request PDF on ResearchGate | Intoxication digitalique en période néonatale: rôle de la déshydratation | Background Despite the great progress which has. Request PDF on ResearchGate | Intoxication digitalique massive. Traitement par hémoperfusion sur résine Amberlite XAD 4 | Haemoperfusion over amberlite.

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Cost-effectiveness analysis of intoxicatipn use of digoxin immune Fab ovine for treatment of digoxin toxicity. At higher concentrations, they increase the ventricular excitability. A second Antidote dose is founded at the onset of clinical signs associated with a pejorative factor Table 4. Thus, the digoxinemia may only be interpreted adequately few days after its administration.

We describe the case of an accidental massive digitalis intoxication in a newborn aged 11 days, which caused a complete atrioventricular block and a state of cardiogenic shock.

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Quick Inventory of Depressive Symptomatology. This article has been cited by other articles in PMC.

Therefore, more calcium is stocked in the sarcoplasmic reticulum, where more calcium is available to the next cellular depolarization and increase in the myocardial contraction Figure 2. In fact, on one hand the antiporter uses the sodium gradient to move calcium to the extracellular space against his own concentration gradient.


Disorders of impulse conduction and impulse formation caused by hyperkalemia in man. intoxicatin

Eur J Clin Pharmacol Drug Interactions of Digitalis. The intoxicahion and safety of the early immunological treatment by Fab antibodies has modified the therapeutical approach and prognostic [7].

Figure 1 Mechanism of contraction of cardiomyocytes. Drug interaction Mechanism and consequence of interaction All hypokalemic drugs diuretics, laxatives, corticosteroids, amphotericin B Increased toxicity of digitalis Calcium by injection Increased toxicity of digitalis Phenobarbital phenytoin Decreased plasma concentrations Table 2: Allergic histories and reactions of patients treated with digoxin immune Fab ovine antibody.

Treatment associated to low- risk situations will include temporary suspension of the therapy, ECG, follow-up and electrolytic supplements if necessary. Cardiac manifestations Responsible for all the prognosis of digitalis intoxication, whatever it might be acute or chronic. Risk factors and manifestations of digoxin toxicity in the elderly. Associated Data Supplementary Materials. As per the Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 of that law and rectify art 36 of that law your personal data.

However, it remains under-used [8]. Copyright and License information Disclaimer. These electrical changes happen to the T wave and the ST segment with a flattening of the T wave, which becomes negative but remains asymmetric, lowering of the J-point and a sub-offset of the ST segment characterized by a cupule to the upper concavity called “cupule digitalis” Figure 3.


J Toxicol Clin Toxicol 2: The digitalis intoxication may occur as a result of a drug interaction Table 2a use of supra-therapeutical doses or a decrease in renal elimination.

The case reminds us, along with the data in the literature, the criteria of wrong prognoses in massive digitalis intoxication in the child and the indications for anti-digoxin antibodies.

Massive digoxin ingestion. Report of a case and review of currently available therapies.

In the presence of at least three pejorative factors: Review of the literature G. The repetition of doses is often necessary.

Two components of the cardiac action potential. N Engl J Med 6: The next sodic influx.

Massive digoxin ingestion. Report of a case and review of currently available therapies.

Behavior and Symptom Identification Scale. Access to the PDF text. The high cost often limits the access to the hospital centers [7].